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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1654082Generated: October 31, 2026

4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine → HCID 15228131, compound

https://huagongshe.com/reaction/1654082

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazineHCID 10360175—
ReactantPotassium tert-butoxideHCID 23665647—
ReactantHCID 135508003HCID 135508003—
ProductHCID 15228131HCID 15228131—

Reaction Steps

Following the same procedure as in Example 23-(c), reaction and treatment were carried out using 360 mg of the above synthesized 5-hydroxy-8-methylquinoline, 1.39 g of 4-(3-chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine and 300 mg of t-BuOK in order to obtain 120 mg of 5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxypropoxy]-8-methylquinoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05405843
Source datasetuspto-grants-1995_04
ORD IDord-08c85ec87ef44e669703d6d0ab99c0a6
Source noteuspto-grants-1995_04