Sodium 3-nitrobenzenesulfonate → 5-Hydroxy-8-methoxyquinoline

HRID 1654083Notes

Reaction equation

HRID 1654083 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:10])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[N+]([C:14]1[CH:15]=C(S([O-])(=O)=O)C=C[CH:19]=1)([O-])=O.[Na+]>OCC(CO)O>[OH:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]2[C:3]=1[CH:19]=[CH:14][CH:15]=[N:1]2

Participants

4

Reactant 2

HCID 31389Sodium 3-nitrobenzenesulfonateHCID 203418413-Amino-4-methoxyphenol

Product 1

HCID 1356893625-Hydroxy-8-methoxyquinoline

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Procedure

Following the same procedure as in Example 23-(a), reaction and treatment were carried out using 2.25 g of 3-amino-4-methoxyphenol, 3.7 ml of glycerol and sodium m-nitrobenzene sulfonate to obtain 180 mg of 5-hydroxy-8-methoxyquinoline.

Workup

  1. customas in Example 23-(a), reaction and treatment

Sources & evidence

ORD record
ord-ffe7baf7b6294e1c829d79e54b923117
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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