2-Methyl-4-(trifluoromethyl)-3-furancarboxylic acid → 2-Methyl-4-(trifluoromethyl)furan

HRID 1654111Notes

Reaction equation

HRID 1654111 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:10]([F:13])([F:12])[F:11])[C:6]=1C(O)=O>S([O-])([O-])(=O)=O.[Cu+2].N1C2C(=CC=CC=2)C=CC=1>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:10]([F:13])([F:12])[F:11])[CH:6]=1

Participants

4

Reactant 1

HCID 218197492-Methyl-4-(trifluoromethyl)-3-furancarboxylic acid

Product 1

HCID 218197502-Methyl-4-(trifluoromethyl)furanYield 59.6%

Reagents, catalysts & solvents 2

HCID 24462Copper SulfateCatalystHCID 7047QuinolineSolvent

Procedure

13.45 g of the product obtained in Stage C were heated at 240° C. for 30 minutes in the presence of 0.6 g of copper (II) sulfate and 10 ml of quinoline. The reaction mixture was dried and distilled under atmospheric pressure to obtain 6.2 g of the expected product with a boiling point of 72°-74° C.

Workup

  1. customThe reaction mixture was dried
  2. distillationdistilled under atmospheric pressure

Sources & evidence

ORD record
ord-b217619b0a3e4b6eb061ac1527ecc43c
Source dataset
uspto-grants-1995_04
Patent number
US05405865

Reaction notes

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