Hydrochloric Acid → 26431-60-7

HRID 1654113Notes

Reaction equation

HRID 1654113 reaction equation
Br[CH2:2][C:3]1[O:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.C1N2CN3CN(C2)CN1C3.Cl.[OH2:23]>>[F:9][C:8]([F:11])([F:10])[C:6]1[CH:7]=[C:3]([CH:2]=[O:23])[O:4][CH:5]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 4101HexamethylenetetramineHCID 218197532-(Bromomethyl)-4-(trifluoromethyl)furan

Product 1

HCID 2181974626431-60-7

Procedure

2.95 g of the product of Stage E, 9 ml of water and 3.6 g of hexamethylenetetramine were refluxed for 1 hour. 9 ml of concentrated hydrochloric acid were added. Reflux was maintained for an additional 1 hour and the mixture was allowed to return to room temperature, diluted with water and extracted with methylene chloride. The extract was washed with water and dried and the solvent was evaporated to obtain 1.9 g of the expected product.

Workup

  1. temperatureReflux
  2. temperaturewas maintained for an additional 1 hour
  3. customto return to room temperature
  4. extractionextracted with methylene chloride
  5. washThe extract was washed with water
  6. customdried
  7. customthe solvent was evaporated

Sources & evidence

ORD record
ord-20a83f6f007a42eb8869c5a2a172f032
Source dataset
uspto-grants-1995_04
Patent number
US05405865

Reaction notes

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