HCID 20079667, compound → HCID 20079651, compound

Participants

Reaction Conditions

Reaction Steps

90 ml of ethynyl magnesium bromide as a 1M solution in tetrahydrofuran and 1.8 g of copper chloride were added to 6.18 g of the product of Stage E in 15 ml of tetrahydrofuran and the mixture was refluxed for 18 hours, cooled to 20° C., poured into a saturated aqueous sodium dihydrogenphosphate solution, and extracted with isopropyl ether. The extract was dried and the solvent evaporated. The residue was chromatographed on silica (eluent: 9/1 hexane/isopropyl ether) to obtain 1.5 g of the expected product.

Provenance & Evidence