反应详情

温度

20 °C

90 ml of ethynyl magnesium bromide as a 1M solution in tetrahydrofuran and 1.8 g of copper chloride were added to 6.18 g of the product of Stage E in 15 ml of tetrahydrofuran and the mixture was refluxed for 18 hours, cooled to 20° C., poured into a saturated aqueous sodium dihydrogenphosphate solution, and extracted with isopropyl ether. The extract was dried and the solvent evaporated. The residue was chromatographed on silica (eluent: 9/1 hexane/isopropyl ether) to obtain 1.5 g of the expected product.

1. temperaturethe mixture was refluxed for 18 hours
2. extractionextracted with isopropyl ether
3. customThe extract was dried
4. customthe solvent evaporated
5. customThe residue was chromatographed on silica (eluent: 9/1 hexane/isopropyl ether)