Hydrochloric Acid → 5-(2-Bromophenyl)-1H-tetrazole

HRID 1654154Notes

Reaction equation

HRID 1654154 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]([Sn](C)(C)C)[N:11]=[N:10][N:9]=1.Cl>C1(C)C=CC=CC=1.C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:12][N:11]=[N:10][N:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 200793455-(2-Bromophenyl)-1-(trimethylstannyl)-1H-tetrazole

Product 1

HCID 1784193735-(2-Bromophenyl)-1H-tetrazole

Reagents, catalysts & solvents 1

HCID 22635083Tetrahydrofuran tolueneSolvent

Procedure

To a solution of 1.0 g of 5-(2-bromophenyl)-1-(trimethylstannyl)-1H-tetrazole in toluene/THF (10:1) at room temperature is added HCl gas, via a bubbler. Gas addition is continued for 5 minutes after the appearance of a precipitate and the solid is then isolated by filtration and washed with hexanes.

Workup

  1. additionGas addition
  2. customafter the appearance of a precipitate and the solid is then isolated by filtration
  3. washwashed with hexanes

Sources & evidence

ORD record
ord-80be410bdb274498be3b8d8ecf6e87b9
Source dataset
uspto-grants-1995_04
Patent number
US05405849

Reaction notes

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