4-(Chlorosulfonyl)benzoic acid → Benzoic Acid

HRID 1654367Notes

Reaction equation

HRID 1654367 reaction equation
NC1C=CC2C=CC3N=C(NC(=O)C(C)(C)C)NC(=O)C=3C=2C=1.ClS([C:28]1[CH:36]=[CH:35][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=1)(=O)=O>N1C=CC=CC=1.O>[C:32]([OH:34])(=[O:33])[C:31]1[CH:35]=[CH:36][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 2

HCID 823854-(Chlorosulfonyl)benzoic acidHCID 135838208HCID 135838208, compound

Product 1

HCID 243Benzoic AcidYield 59.8%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

To a solution of N-(9-Amino-1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide (1.38 g, 4.5 mmoles) in dry pyridine (10 ml) was added 4-(chlorosulfonyl)benzoic acid (5.0 g, 22.6 mmoles) at room temperature under a nitrogen atmosphere. After stirring for 3 days, the pyridine was removed under reduced pressure to leave a gummy brown residue which was suspended in water (30 ml), filtered, washed with water and dried to give 4-((N-(1,2-dihydro-1-oxobenzo[f]quinazolin-3-yl)pivalamide)-9-yl)amino)sulfonyl)benzoic acid (1.65 g).

Workup

  1. customthe pyridine was removed under reduced pressure
  2. customto leave a gummy brown residue which
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-0383176c726c41c881cec29cf8e5cacb
Source dataset
uspto-grants-1995_04
Patent number
US05405851

Reaction notes

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