Dicyclohexylcarbodiimide → HCID 20077725, compound

HRID 1654433Notes

Reaction equation

HRID 1654433 reaction equation
[CH:1]1([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([F:20])[C:12]=2[F:21])[CH2:3][CH2:2]1.[CH:22]1(N=C=NC2CCCCC2)CCCC[CH2:23]1.CN(C1C=CC=CN=1)C.C(C1C=NC(C2C=CC(O)=CC=2)=NC=1)CCCCCCC>C(Cl)Cl>[CH:2]1([CH2:3][CH2:1][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[C:13]([F:20])[C:12]=2[F:21])[CH2:23][CH2:22]1

Participants

6

Reactant 4

HCID 10868DicyclohexylcarbodiimideHCID 218852-DimethylaminopyridineHCID 6040552-(4-Hydroxyphenyl)-5-octylpyrimidineHCID 14817096HCID 14817096, compound

Product 1

HCID 20077725HCID 20077725, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.2 g of 4-(6-cyclopropylhexyloxy)-2,3-difluorobenzoic acid were added to a solution of 0.84 g of dicyclohexyl-carbodiimide, 50 mg of dimethylaminopyridine and 1.15 g of 4-(5-octylpyrimidin-2-yl)phenol in 50 ml of methylene chloride. After a reaction time of 24 hours, the precipitate (dicyclohexylurea) was filtered off with suction. The filtrate was freed from solvent and chromatographed (SiO2, CH2Cl2).

Workup

  1. filtrationAfter a reaction time of 24 hours, the precipitate (dicyclohexylurea) was filtered off with suction
  2. customchromatographed (SiO2, CH2Cl2)

Sources & evidence

ORD record
ord-070ee32d385f4d24b83dd4fb8fcfc03f
Source dataset
uspto-grants-1995_04
Patent number
US05407599

Reaction notes

Loading…