1H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)- → HCID 20078043, compound

HRID 1654485Notes

Reaction equation

HRID 1654485 reaction equation
[NH2:1][C:2]1[C:3]([Cl:21])=[CH:4][C:5]2[N:9]=[C:8]([N:10]3[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]3)[N:7]([CH:17]([CH3:19])[CH3:18])[C:6]=2[CH:20]=1.[ClH:22].C(O)C>C(O)C>[ClH:21].[ClH:22].[NH2:1][C:2]1[C:3]([Cl:21])=[CH:4][C:5]2[N:9]=[C:8]([N:10]3[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]3)[N:7]([CH:17]([CH3:19])[CH3:18])[C:6]=2[CH:20]=1

Participants

4

Reactant 2

HCID 30732911H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)-HCID 21887872Ethanol hydrochloride

Product 1

HCID 20078043HCID 20078043, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole (2.0 g) was dissolved in ethanol (5 ml) and thereto was added 11% (w/w) hydrochloric acid-ethanol (10 ml). After cooling, the precipitated crystal was separated by filtration and the obtained crystal was recrystallized from a mixed solvent of ethanol-methanol to give 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole dihydrochloride (1.7 g) as colorless crystal.

Workup

  1. temperatureAfter cooling
  2. customthe precipitated crystal was separated by filtration
  3. customthe obtained crystal was recrystallized from a mixed solvent of ethanol-methanol

Sources & evidence

ORD record
ord-74ce06a0cdef448695ff7ba5fc26e99e
Source dataset
uspto-grants-1995_04
Patent number
US05407936

Reaction notes

Loading…