1H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)- → HCID 20078043, compound

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Reaction Steps

6-Amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole (2.0 g) was dissolved in ethanol (5 ml) and thereto was added 11% (w/w) hydrochloric acid-ethanol (10 ml). After cooling, the precipitated crystal was separated by filtration and the obtained crystal was recrystallized from a mixed solvent of ethanol-methanol to give 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole dihydrochloride (1.7 g) as colorless crystal.

Provenance & Evidence