Maleic Acid → HCID 10459925, compound

HRID 1654486Notes

Reaction equation

HRID 1654486 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[NH2:9][C:10]1[C:11]([Cl:29])=[CH:12][C:13]2[N:17]=[C:16]([N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)[N:15]([CH:25]([CH3:27])[CH3:26])[C:14]=2[CH:28]=1>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[NH2:9][C:10]1[C:11]([Cl:29])=[CH:12][C:13]2[N:17]=[C:16]([N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)[N:15]([CH:25]([CH3:27])[CH3:26])[C:14]=2[CH:28]=1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 30732911H-Benzimidazol-6-amine, 5-chloro-1-(1-methylethyl)-2-(4-methyl-1-piperazinyl)-

Product 1

HCID 10459925HCID 10459925, compoundYield 68.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Methanol (5 ml) was added to maleic acid (0.8 g) and the mixture was heated to dissolve. To the solution was added 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1-piperazinyl)benzimidazole (1.0 g) dissolved in methanol (5 ml). After cooling, the precipitated crystal was separated by filtration off and the obtained crystal was recrystallized from acetonitrile to give 6-amino-5-chloro-1-isopropyl-2-(4-methyl-1piperazinyl)benzimidazole dimaleate (1.2 g) as colorless crystal.

Workup

  1. temperaturethe mixture was heated to dissolve
  2. temperatureAfter cooling
  3. customthe precipitated crystal was separated by filtration off and the obtained crystal
  4. customwas recrystallized from acetonitrile

Sources & evidence

ORD record
ord-3317911cb209450bb0663b158a4a01a4
Source dataset
uspto-grants-1995_04
Patent number
US05407936

Reaction notes

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