反应详情

4-Aminomethyl-4-hydroxy-1-methylpiperidine (0.83 g., 5.7 mmole) was dissolved in 10 ml. chloroform, and acetic anhydride (0.58 g., 5.7 mmole) was added. The reaction mixture warmed spontaneously to 40°-50° C. After 30 minutes, the solvent was evaporated and the crude residue was chromatographed on a silica gel column (Merck 7734), using 33:67 2% aqueous ammonia-methanol as eluent.

1. temperatureThe reaction mixture warmed spontaneously to 40°-50° C
2. customthe solvent was evaporated
3. customthe crude residue was chromatographed on a silica gel column (Merck 7734)