HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Rupatadine trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Rupatadine | HCID 133017 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Rupatadine trihydrochloride | HCID 133016 | — |
Reaction Steps
To a cooled (0° C.) solution of 1.13 g of the compound obtained in example 4 in ethyl acetate, was added a diethyl ether solution saturated with hydrochloric acid gas, to give the title compound of this example as a white solid (yield: 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407941 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-e18c617d1a70484a820ed0b5b1a575b9 |
| Source note | uspto-grants-1995_04 |