Hydrochloric Acid → Rupatadine trihydrochloride

HRID 1654493Notes

Reaction equation

HRID 1654493 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[C:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[N:25][CH:26]=[C:27]([CH3:29])[CH:28]=4)[CH2:18][CH2:17]3)[C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:30]=1.C(OCC)C.[ClH:36]>C(OCC)(=O)C>[ClH:1].[ClH:36].[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:15](=[C:16]3[CH2:21][CH2:20][N:19]([CH2:22][C:23]4[CH:24]=[N:25][CH:26]=[C:27]([CH3:29])[CH:28]=4)[CH2:18][CH2:17]3)[C:10]3=[N:11][CH:12]=[CH:13][CH:14]=[C:9]3[CH2:8][CH2:7][C:6]=2[CH:30]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 133017Rupatadine

Product 1

HCID 133016Rupatadine trihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a cooled (0° C.) solution of 1.13 g of the compound obtained in example 4 in ethyl acetate, was added a diethyl ether solution saturated with hydrochloric acid gas, to give the title compound of this example as a white solid (yield: 80%).

Sources & evidence

ORD record
ord-e18c617d1a70484a820ed0b5b1a575b9
Source dataset
uspto-grants-1995_04
Patent number
US05407941

Reaction notes

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