1,1,1-Trifluoro-2-iodoethane → HCID 20078114, compound

HRID 1654502Notes

Reaction equation

HRID 1654502 reaction equation
[SH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH:9]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[F:26][C:27]([F:31])([F:30])[CH2:28]I>>[CH:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH2:15][O:14][C:10]1[CH:9]=[C:8]([C:2]2([S:1][CH2:28][C:27]([F:31])([F:30])[F:26])[CH2:7][CH2:6][O:5][CH2:4][CH2:3]2)[CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 20078116HCID 20078116, compound

Product 1

HCID 20078114HCID 20078114, compoundYield 61%

Procedure

Using a similar procedure to that described in Example 1, 4-mercapto-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran was reacted with 2,2,2-trifluoroethyl iodide to give 4-[3-(naphth-2ylmethoxy)phenyl]-4-(2,2,2-trifluoroethylthio)tetrahydropyran in 61% yield, m.p. 76°-78° C.

Sources & evidence

ORD record
ord-b55c0665be7e4a5780771a52829f719f
Source dataset
uspto-grants-1995_04
Patent number
US05407945

Reaction notes

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