Hydrochloric Acid → 7-(1-Amino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride salt

HRID 1654517Notes

Reaction equation

C(OC([NH:8][CH:9]1[C:11]2([CH2:16][CH2:15][N:14]([C:17]3[CH:26]=[C:25]4[C:20]([C:21](=[O:33])[C:22]([C:30]([OH:32])=[O:31])=[CH:23][N:24]4[CH:27]4[CH2:29][CH2:28]4)=[CH:19][C:18]=3[F:34])[CH2:13][CH2:12]2)[CH2:10]1)=O)(C)(C)C.[ClH:35]>>[ClH:35].[NH2:8][CH:9]1[C:11]2([CH2:16][CH2:15][N:14]([C:17]3[CH:26]=[C:25]4[C:20]([C:21](=[O:33])[C:22]([C:30]([OH:32])=[O:31])=[CH:23][N:24]4[CH:27]4[CH2:28][CH2:29]4)=[CH:19][C:18]=3[F:34])[CH2:13][CH2:12]2)[CH2:10]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 675530147-(1-tert-Butoxycarbonylamino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

Product 1

HCID 1317189637-(1-Amino-6-azaspiro[2.5]oct-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride saltYield 60%

Procedure

According to the procedure of example 1B, the compound of step A (420 mg, 0.89 mmol) was hydrolyzed with hydrochloric acid to provide the title product, mp 218° C. (decomp.), 197 mg (0.53 mmol, 60% yield).

Sources & evidence

ORD record: ord-8dad6f6dbe6b496a9d276d3dd04b9467
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05407943

Reaction notes

Loading…