Hydrochloric Acid → ethyl 4-(2-aminoethyl)-Cyclohexyl-acetate

HRID 1654525Notes

Reaction equation

HRID 1654525 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][CH:6]=1.Cl>C(O)C.[Ru](=O)=O>[NH2:2][CH2:3][CH2:4][CH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:7][CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 20463408HCID 20463408, compound

Product 1

HCID 14624905ethyl 4-(2-aminoethyl)-Cyclohexyl-acetateYield 90%

Reagents, catalysts & solvents 2

HCID 82848Ruthenium dioxideCatalystHCID 702EthanolSolvent

Procedure

by hydrogenation of ethyl 4-(aminoethyl)-phenylacetate hydrochloride in the presence of ruthenium dioxide in ethanol. Yield 90% of theory; hydrochloride m.p. 108°-110° C.

Sources & evidence

ORD record
ord-b9411720002a4f6ea949ad4836434f6a
Source dataset
uspto-grants-1995_04
Patent number
US05407951

Reaction notes

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