HCID 20078507, compound → HCID 53776937, compound

HRID 1654527Notes

Reaction equation

HRID 1654527 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][CH:7]=1>C(O)C.[Rh]>[NH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][CH:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1

Participants

4

Reactant 1

HCID 20078507HCID 20078507, compound

Product 1

HCID 53776937HCID 53776937, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 702EthanolSolvent

Procedure

by hydrogenation of ethyl 4-(3-aminopropyl)-phenylacetate hydrochloride in the presence of rhodium in ethanol. Yield 90% of theory; m.p. 99°-103° C.

Sources & evidence

ORD record
ord-b422525b4c754a6c9a2690255954bb0f
Source dataset
uspto-grants-1995_04
Patent number
US05407951

Reaction notes

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