HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 4-[2-(4-cyanobenzenesulphonylamino)-ethyl]-cyclohexylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Cyanobenzenesulfonyl chloride | HCID 39497 | — |
| Reactant | HCID 67807757 | HCID 67807757 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 4-[2-(4-cyanobenzenesulphonylamino)-ethyl]-cyclohexylacetate | HCID 20078478 | 95% |
Reaction Steps
by the reaction of 4-cyanobenzenesulphonylchloride with ethyl 4-(2-aminoethyl)-cyclohexylacetate hydrochloride in methylene chloride in the presence of triethylamine. Yield 95% of theory, colourless oil. 1H-NMR (300 MHz, d6 -DMSO): δ=2.12 and 2.21 (2d, J=7 Hz, addl. 2H, CH2COOEt); 2.75-2.85 (m, 2H, NHCH2); 7.78 (t, J=4 Hz, 1H, SO2NH); 7.91-8.08 (m, 4H, aromatic protons).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05407951 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-58a2f06c55024596a3416b930419d53b |
| Source note | uspto-grants-1995_04 |