反应详情

by the reaction of 4-cyanobenzenesulphonylchloride with ethyl 4-(2-aminoethyl)-cyclohexylacetate hydrochloride in methylene chloride in the presence of triethylamine. Yield 95% of theory, colourless oil. 1H-NMR (300 MHz, d6 -DMSO): δ=2.12 and 2.21 (2d, J=7 Hz, addl. 2H, CH2COOEt); 2.75-2.85 (m, 2H, NHCH2); 7.78 (t, J=4 Hz, 1H, SO2NH); 7.91-8.08 (m, 4H, aromatic protons).