反应详情

A mixture of di-tert-butyl Bis(3-phthalimidopropyl)malonate (Step A) (6 g, 10.16 mmol), a catalytic amount of PTSA in 60 mL of toluene is heated to reflux for 4 hours. The reaction is cooled and a solid is filtered and dried. The solid is heated neat (under a nitrogen atmosphere) for 2 hours. From this procedure 3.81 g of Bis(3-phthalimidopropyl)acetic acid is isolated.

1. temperatureto reflux for 4 hours
2. temperatureThe reaction is cooled
3. filtrationa solid is filtered
4. customdried
5. temperatureThe solid is heated neat (under a nitrogen atmosphere) for 2 hours