3-(4,4'-dimethoxybenzhydryl)-2-propyl-6-nitroquinazolin-4(3H)-one → HCID 19934842, compound

HRID 1654669Notes

Reaction equation

HRID 1654669 reaction equation
[CH3:1][O:2][C:3]1[CH:34]=[CH:33][C:6]([CH:7]([N:16]2[C:25](=[O:26])[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([N+:27]([O-])=O)[CH:23]=3)[N:18]=[C:17]2[CH2:30][CH2:31][CH3:32])[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1>CCOC(C)=O.[Pd]>[NH2:27][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][CH:21]=1)[N:18]=[C:17]([CH2:30][CH2:31][CH3:32])[N:16]([CH:7]([C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:34][CH:33]=1)[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:25]2=[O:26]

Participants

4

Reactant 1

HCID 200766253-(4,4'-dimethoxybenzhydryl)-2-propyl-6-nitroquinazolin-4(3H)-one

Product 1

HCID 19934842HCID 19934842, compoundYield 72%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 12.1 g (26.0 mmol) of 3-(4,4'-dimethoxybenzhydryl)-2-propyl-6-nitro-quinazolin-4-(3H )-one dissolved in 250 ml of EtOAc was hydrogenated under atmospheric pressure over three days in the presence of three portions of 1.2 g of 10% Pd/C added daily. The mixture was filtered through celite and concentrated in vacuo to give an oil. The product was purified by flash chromatography over silica gel eluting with 50% EtOAc/hexanes to give 7.8 g (18.7 mmol) of the amine. 72% yield. 1H-NMR (CDCl3):0.82 (t, 3H, J=7.2 Hz), 1.49 (bm, 2H), 2.61 (t, 2H, J=7.81 Hz), 3.79 (s, 6H), 3.90 (bs, 2H), 6.85 (d, 4H, J=8.8 Hz), 7.08 (dd, 1H, J=2.8, 8.7 Hz), 7.20 (d, 4H, J=8.4 Hz), 7.42 (d, 1H, J=2.7 Hz), 7.47 (d, 1H, J=8.7 Hz).

Workup

  1. additionadded daily
  2. filtrationThe mixture was filtered through celite and
  3. concentrationconcentrated in vacuo
  4. customto give an oil
  5. customThe product was purified by flash chromatography over silica gel eluting with 50% EtOAc/hexanes

Sources & evidence

ORD record
ord-3d159a6cdf184fa7a0441be06070a1f8
Source dataset
uspto-grants-1995_04
Patent number
US05409926

Reaction notes

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