Thionyl Chloride → Benzene, 1-(chloromethyl)-4-(phenylmethyl)-

HRID 1654700Notes

Reaction equation

HRID 1654700 reaction equation
[CH2:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12]O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:18])=O>C(Cl)(Cl)Cl>[CH2:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][Cl:18])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 5976144-(Phenylmethyl)benzenemethanol

Product 1

HCID 84334Benzene, 1-(chloromethyl)-4-(phenylmethyl)-

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
0 °C

Procedure

4-benzylbenzyl alcohol (181.47 g) was dissolved into chloroform (100 ml), and thionyl chloride (66.8 ml) was added with stirring at a 0° C. After stirring at 0° C. for 4 hours, reaction mixture was concentrated under reduced pressure to give the title compound (198.34 g). This product was used in the subsequent procedure without purification.

Workup

  1. additionwas added
  2. stirringAfter stirring at 0° C. for 4 hours
  3. customreaction mixture
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-c2e8066147ea49d88dd46e764deb3f52
Source dataset
uspto-grants-1995_04
Patent number
US05409928

Reaction notes

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