Hydrochloric Acid → HCID 178524698, compound

HRID 1654707Notes

Reaction equation

HRID 1654707 reaction equation
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][N:17]3[C:22]([OH:23])=[C:21]([C:24]([O:26]CC)=[O:25])[CH:20]=[N:19][C:18]=23)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].C(O)C.Cl>O>[CH2:1]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:15]=[N:16][N:17]3[C:22]([OH:23])=[C:21]([C:24]([OH:26])=[O:25])[CH:20]=[N:19][C:18]=23)=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 178469482HCID 178469482, compound

Product 1

HCID 178524698HCID 178524698, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 3-(4-benzylphenyl)-6-ethoxycarbonyl-7-hydroxypyrazolo[1,5-a]pyrimidine (1.35 g), sodium hydroxide (1.50 g), ethanol (35 ml) and water (35 ml) was stirred under heating reflux for 2 hours. Then, to the reaction mixture was added water (50 ml), and hydrochloric acid was added at 0° C. to adjust to acid. After stirring for 30 minutes, the precipitate was separated by filtration, washed with water, and dried to give the title compound (1.24 g).

Workup

  1. temperatureunder heating
  2. temperaturereflux for 2 hours
  3. additionwas added at 0° C.
  4. stirringAfter stirring for 30 minutes
  5. customthe precipitate was separated by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-085a540925f2429c86e8c974bec26052
Source dataset
uspto-grants-1995_04
Patent number
US05409928

Reaction notes

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