Hydrochloric Acid → HCID 178438917, compound

HRID 1654732Notes

Reaction equation

HRID 1654732 reaction equation
C([C:4]1[CH:5]=[N:6][C:7]2[N:8]([N:11]=[CH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[C:9]=1[OH:10])(O)=O.NC1C=CC=CC=1.Cl>O>[OH:10][C:9]1[N:8]2[N:11]=[CH:12][C:13]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)([CH3:22])[CH3:21])=[CH:16][CH:15]=3)=[C:7]2[N:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 178438918HCID 178438918, compound

Product 1

HCID 178438917HCID 178438917, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

To 6-carboxy-7-hydroxy-3-[4-(2-phenylpropan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidine (950 mg) was added aniline (7.0 ml), and the mixture was stirred at 100° C. for 3 hours. To the reaction mixture was added water (20 ml) under ice-cooling. The mixture was adjusted to acid with 10% hydrochloric acid, and the precipitate was separated by filtration, washed with 30% methanol-water to give the title compound (830 mg) at a quantitative yield.

Workup

  1. temperaturecooling
  2. customthe precipitate was separated by filtration
  3. washwashed with 30% methanol-water

Sources & evidence

ORD record
ord-e8b895dec601436bb2e7b2bac88135a3
Source dataset
uspto-grants-1995_04
Patent number
US05409928

Reaction notes

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