反应详情

Lithium aluminium hydride (92 mg, 2.5 mmol) was added to a stirred solution of 2-(cyanomethyl)-5-(4-fluorophenyl)hexahydrofuro[2,3-b]furan (300 mg, 1.2 mmol) in dry THF. The reaction mixture was stirred overnight and water (0.9 ml), 15% sodium hydroxide (0.9 ml) and water (2.7 ml) are added in succession. The white percipitate was filtered off and the solvent removed under reduced pressure to give crude 5-(2-aminoethyl)-2-(4-fluorophenyl)hexahydrofuro[2,3-b]furan which is used directly in the next step.

1. filtrationThe white percipitate was filtered off
2. customthe solvent removed under reduced pressure