反应详情

A mixture of 2-amino-3-benzyloxypyridine (4.0 g, 20 mmol) and ethyl 2-methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 1 hour. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol 10:1). The product was obtained as a white crystalline solid (1.2 g), m.p. 119°-120° C.

1. temperaturewas heated
2. temperatureunder reflux for 1 hour
3. customEvaporation of the solvent
4. customgave an oil which
5. customwas purified by flash chromatography (chloroform/methanol 10:1)