HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-benzyloxypyridine → HCID 178424236, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-benzyloxypyridine | HCID 90334 | — |
| Reactant | Ethyl 2-(2-methylphenyl)ethanimidate--hydrogen chloride (1/1) | HCID 20076957 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178424236 | HCID 178424236 | 16.3% |
Reaction Steps
A mixture of 2-amino-3-benzyloxypyridine (4.0 g, 20 mmol) and ethyl 2-methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 1 hour. Evaporation of the solvent gave an oil which was purified by flash chromatography (chloroform/methanol 10:1). The product was obtained as a white crystalline solid (1.2 g), m.p. 119°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-049250a943704aeb8ebcbc38a4d55cc8 |
| Source note | uspto-grants-1995_04 |