Hydrochloric Acid → Ethyl 4-methoxyphenylacetimidate hydrochloride

Participants

Reaction Steps

A solution of 4-methoxyphenylacetonitrile (50 g, 0.34 mol) in absolute ethanol (200 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (66 g, 84%), then used in subsequent steps without further purification.

Provenance & Evidence