Hydrochloric Acid → Ethyl 4-methoxyphenylacetimidate hydrochloride

HRID 1654813Notes

Reaction equation

HRID 1654813 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1.[ClH:12].[CH2:13]([OH:15])[CH3:14]>>[ClH:12].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[NH:11])[O:15][CH2:13][CH3:14])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 66031Benzeneacetonitrile, 4-methoxy-

Product 1

HCID 12238406Ethyl 4-methoxyphenylacetimidate hydrochloride

Procedure

A solution of 4-methoxyphenylacetonitrile (50 g, 0.34 mol) in absolute ethanol (200 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (66 g, 84%), then used in subsequent steps without further purification.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residual oil triturated with ether
  3. filtrationThe solid was filtered off
  4. washwashed with ether
  5. customdried (66 g, 84%)
  6. customused in subsequent steps without further purification

Sources & evidence

ORD record
ord-6cbe76f1f6274fb49fe0b5fbe463d39e
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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