反应详情

A solution of 4-methoxyphenylacetonitrile (50 g, 0.34 mol) in absolute ethanol (200 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (66 g, 84%), then used in subsequent steps without further purification.

1. customThe solvent was evaporated in vacuo
2. customthe residual oil triturated with ether
3. filtrationThe solid was filtered off
4. washwashed with ether
5. customdried (66 g, 84%)
6. customused in subsequent steps without further purification