Hydrochloric Acid → HCID 13780008, compound

HRID 1654815Notes

Reaction equation

HRID 1654815 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.[ClH:11].[CH2:12]([OH:14])[CH3:13]>>[ClH:11].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[NH:10])[O:14][CH2:12][CH3:13])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68016Benzeneacetonitrile, 4-fluoro-

Product 1

HCID 13780008HCID 13780008, compound

Procedure

A solution of 4-fluorophenylacetonitrile (50 g, 0.37 mol) in absolute ethanol (300 ml) was treated with dry HCl gas with ice cooling for 1 hour. The solvent was evaporated in vacuo, and the residual oil triturated with ether. The solid was filtered off, washed with ether and dried (67 g, 83%), then used in subsequent steps without further purification.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residual oil triturated with ether
  3. filtrationThe solid was filtered off
  4. washwashed with ether
  5. customdried (67 g, 83%)
  6. customused in subsequent steps without further purification

Sources & evidence

ORD record
ord-87282633a3e2443c9ec8310da6db4163
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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