反应详情

A mixture of 2-amino-3-(4-fluorobenzyloxy)pyridine (4.36 g, 20 mmol) and ethyl 2methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil, which was purified by flash chromatography (chloroform/methanol) to obtain the product (1.2 g), m.p. 199°-200° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customEvaporation of the solvent
4. customgave an oil, which
5. customwas purified by flash chromatography (chloroform/methanol)