HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(4-Fluorophenyl)methoxy]pyridin-2-amine → HCID 178424238, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(4-Fluorophenyl)methoxy]pyridin-2-amine | HCID 2728377 | — |
| Reactant | Ethyl 2-(2-methylphenyl)ethanimidate--hydrogen chloride (1/1) | HCID 20076957 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178424238 | HCID 178424238 | 15.5% |
Reaction Steps
A mixture of 2-amino-3-(4-fluorobenzyloxy)pyridine (4.36 g, 20 mmol) and ethyl 2methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave an oil, which was purified by flash chromatography (chloroform/methanol) to obtain the product (1.2 g), m.p. 199°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-b0806e91fa0442838291a368a6a46039 |
| Source note | uspto-grants-1995_04 |