HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,6-Difluoro-benzyloxy)-pyridin-2-ylamine → HCID 178424240, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,6-Difluoro-benzyloxy)-pyridin-2-ylamine | HCID 10263498 | — |
| Reactant | Ethyl 2-(2-methylphenyl)ethanimidate--hydrogen chloride (1/1) | HCID 20076957 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178424240 | HCID 178424240 | 2.2% |
Reaction Steps
A mixture of 2-amino-3-(2,6-difluorobenzyloxy)pyridine (4.72 g, 20 mmol) and ethyl 2methylphenylacetimidate hydrochloride (4.69 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave art oil which was purified by flash chromatography (chloroform/methanol) to obtain the product (0.18 g), m.p. 127°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05409943 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-87629e4cffcf46c381e02fa76dd42a51 |
| Source note | uspto-grants-1995_04 |