反应详情

A mixture of 2-amino-3-(2-bromobenzyloxy)pyridine (5.58 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave a residue which was purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.28 g), m.p. 158°-169° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. customEvaporation of the solvent
4. customgave a residue which
5. customwas purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether