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2-Amino-3-(2-bromobenzyloxy)pyridine → N'-[3-[(2-bromophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3-(2-bromobenzyloxy)pyridine | HCID 10468808 | — |
| 反応物 | Ethyl 2-phenylacetimidate hydrochloride | HCID 12218775 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N'-[3-[(2-bromophenyl)methoxy]-2-pyridinyl]-2-phenylethanimidamide | HCID 178510792 | 3.5% |
反応手順
A mixture of 2-amino-3-(2-bromobenzyloxy)pyridine (5.58 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave a residue which was purified by chromatography (silica, chloroform/methanol) and recrystallisation from ethanol/ether to obtain the product (0.28 g), m.p. 158°-169° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05409943 |
| 出典データセット | uspto-grants-1995_04 |
| ORD ID | ord-0a3816cd36fe4debac1ed2ba97b645ff |
| 出典メモ | uspto-grants-1995_04 |