Ethyl 2-phenylacetimidate hydrochloride → HCID 178466713, compound

HRID 1654850Notes

Reaction equation

HRID 1654850 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:17].[C:18]1([CH2:24][C:25](=[NH:29])OCC)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[ClH:17].[C:11]1([CH:9]([O:8][C:7]2[C:2]([NH:1][C:25](=[NH:29])[CH2:24][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[N:3][CH:4]=[CH:5][CH:6]=2)[CH3:10])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 12218775Ethyl 2-phenylacetimidate hydrochlorideHCID 127582763-(1-Phenylethoxy)pyridin-2-amine

Product 1

HCID 178466713HCID 178466713, compoundYield 14.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-amino-3-(1-phenylethoxy)pyridine (4.28 g, 20 mmol) and ethyl phenylacetimidate hydrochloride (4.39 g, 22 mmol) in ethanol (80 ml) was heated under reflux for 2 hours. Evaporation of the solvent gave a residue which was purified by chromatography (silica, chloroform/methanol) to obtain the product (1.05 g), m.p. 75°-80° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customEvaporation of the solvent
  4. customgave a residue which
  5. customwas purified by chromatography (silica, chloroform/methanol)

Sources & evidence

ORD record
ord-f9a1824080e14d75a075fc498deb3ab3
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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