6-Methyl-2-nitropyridin-3-ol → 2-Amino-6-methylpyridin-3-ol

HRID 1654851Notes

Reaction equation

HRID 1654851 reaction equation
[OH:1][C:2]1[C:3]([N+:9]([O-])=O)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1>C(O)C.[Pd]>[NH2:9][C:3]1[C:2]([OH:1])=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=1

Participants

4

Reactant 1

HCID 848016-Methyl-2-nitropyridin-3-ol

Product 1

HCID 885002-Amino-6-methylpyridin-3-olYield 180.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-Hydroxy-6-methyl-2-nitropyridine (25 g, 0.162 g) was dissolved in ethanol (600 ml) and hydrogenated over 10% palladium-charcoal (3.3 g) at 50 p.s.i. Removal of the catalyst and evaporation of the solvent gave the product (36.4 g, 91%), m.p. 147°-149° C.

Workup

  1. customRemoval of the catalyst and evaporation of the solvent

Sources & evidence

ORD record
ord-cd6e5b5af91f4cd99e1e6227bb2d14ac
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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