Hydrochloric Acid → HCID 12283339, compound

HRID 1654860Notes

Reaction equation

HRID 1654860 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#[N:6].Cl.[CH2:12]([OH:14])[CH3:13]>>[ClH:1].[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5](=[NH:6])[O:14][CH2:12][CH3:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 76112(o-Chlorophenyl)acetonitrile

Product 1

HCID 12283339HCID 12283339, compound

Procedure

A solution of 2-chlorobenzyl cyanide (32.4 g, 0.214 mol) in ethanol (70 ml) was cooled to 5 ° C., then HCl gas was passed through with stirring for 30 minutes and the resultant mixture was allowed to stand at room temperature for 18 hours. Evaporation of the solvent and trituration with ether gave the desired product, which was used immediately without further purification. Yield 49.0 g (98%).

Workup

  1. waitto stand at room temperature for 18 hours
  2. customEvaporation of the solvent and trituration with ether

Sources & evidence

ORD record
ord-95bda6eee6dc473f8c84a689b254781a
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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