Diethyl Ether → HCID 20077013, compound

HRID 1654862Notes

Reaction equation

HRID 1654862 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[S:25])=[CH:19][CH:18]=1.CCOCC>C1(C)C=CC=CC=1>[CH2:9]([O:8][C:7]1[C:2]([NH:1][C:24]([NH:23][C:20]2[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=2)=[S:25])=[N:3][CH:4]=[CH:5][CH:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 164804-Chlorophenyl isothiocyanateHCID 903342-Amino-3-benzyloxypyridine

Product 1

HCID 20077013HCID 20077013, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A stirring mixture of 2-amino-3-benzyloxy pyridine (5.37 g, 0.0268 mol) and 4-chlorophenylisothiocyanate (5 g, 0.0295 mol) in toluene (20 ml) was heated under reflux for 2 h. After allowing to cool, the solution was treated with ether, and the resulting solid filtered off, washed and dried. Yield 8.33 g (84%), m.p. 140°-143 ° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureto cool
  4. filtrationthe resulting solid filtered off
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-f1da553ee2d947b89c05396b4a5db1ad
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

Loading…