Diethyl Ether → HCID 20076927, compound

HRID 1654864Notes

Reaction equation

HRID 1654864 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:16]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[S:26])=[CH:20][CH:19]=1)#[N:17].CCOCC>C1(C)C=CC=CC=1>[CH2:9]([O:8][C:7]1[C:2]([NH:1][C:25]([NH:24][C:21]2[CH:22]=[CH:23][C:18]([C:16]#[N:17])=[CH:19][CH:20]=2)=[S:26])=[N:3][CH:4]=[CH:5][CH:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 17626Benzonitrile, 4-isothiocyanato-HCID 903342-Amino-3-benzyloxypyridine

Product 1

HCID 20076927HCID 20076927, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A stirring mixture of 2-amino-3-benzyloxy pyridine (5.68 g, 0.0284 mol) and 4cyanophenyl isothiocyanate (5 g, 0.0312 mol) in toluene (20 ml) was heated under reflux for 2 h. After allowing to cool, the solution was treated with ether, and the resulting solid filtered off, washed and dried. Yield 9.4 g (92%), m.p. 163°-165 ° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureto cool
  4. filtrationthe resulting solid filtered off
  5. washwashed
  6. customdried

Sources & evidence

ORD record
ord-6543e603af7f40f7be385385ac2387da
Source dataset
uspto-grants-1995_04
Patent number
US05409943

Reaction notes

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