Phenylmethyl 4-(2,3-dihydro-1H-inden-2-yl)-2-butenoate → HCID 10465518, compound

HRID 1654943Notes

Reaction equation

HRID 1654943 reaction equation
C([O:8][C:9](=[O:22])[CH:10]=[CH:11][CH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH2:21]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH:13]1[CH2:12][CH2:11][CH2:10][C:9]([OH:22])=[O:8]

Participants

5

Reactant 2

HCID 54078263Phenylmethyl 4-(2,3-dihydro-1H-inden-2-yl)-2-butenoateHCID 178418361HCID 178418361, compound

Product 1

HCID 10465518HCID 10465518, compoundYield 85.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6.45 g (22.1 mmol) of benzyl-4-(indan-2-yl)-2-butenoate was dissolved in 120 ml of methanol, to which 0.6 g of 10% palladium on carbon was added and stirred vigorously for 2.5 hours in the stream of hydrogen. The catalyst was removed by filtration, the filtrate was condensed to obtain 3.84 g of crystalline 4-(indan-2-yl)butanoic acid. Yield: 85%

Workup

  1. additionwas added
  2. customThe catalyst was removed by filtration
  3. customcondensed

Sources & evidence

ORD record
ord-c533f9fc83d5471ab0aa69b2bed35a84
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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