Water → HCID 18921531, compound

HRID 1654945Notes

Reaction equation

HRID 1654945 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH:8]1[CH2:16][C:17]([NH2:19])=O.O.[OH-].[Na+]>O1CCCC1>[CH2:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:7][CH:8]1[CH2:16][CH2:17][NH2:19]

Participants

6

Reactant 4

HCID 962Water2×HCID 14798Sodium HydroxideHCID 189215242-(2,3-Dihydro-1H-inden-2-yl)acetamideHCID 21226445Aluminium lithium hydride

Product 1

HCID 18921531HCID 18921531, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

8.77 g (0.23 mol) of lithium aluminum hydride was suspended in 400 ml of tetrahydrofuran, to which was added a suspension of 100 ml tetrahydrofuran containing 27.8 g (0.160 mol) of (indan-2-yl)acetamide under ice-cooling. The mixture was stirred for 30 minutes at room temperature, then refluxed for 5 hours. Under ice-cooling, 9 ml of water, 9 ml of 15% sodium hydroxide and 26 ml water were added thereto dropwise in this order for decomposing the excessive reagent and separating the solid matter. The filtrate was condensed to obtain 26.1 g of an oily material. Yield: 100%

Workup

  1. additionwas added
  2. temperaturecooling
  3. temperaturerefluxed for 5 hours
  4. temperatureUnder ice-cooling
  5. customseparating the solid matter
  6. customcondensed

Sources & evidence

ORD record
ord-94b8b9d8149f433ca23e88d39af0c718
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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