HCID 15290057, compound → HCID 15290058, compound

HRID 1654948Notes

Reaction equation

HRID 1654948 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH:15]2[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH2:24][C:25]([OH:27])=[O:26])[CH:21]=3)[CH2:16]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][CH2:14][CH:15]2[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[C:20]([CH2:24][C:25]([OH:27])=[O:26])[CH:21]=3)[CH2:16]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 15290057HCID 15290057, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15290058HCID 15290058, compoundYield 79.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.95 g of [2-[(4-nitrophenyl)sulfonylaminomethyl)indan-5-yl]acetic acid obtained in Example 22 was dissolved in 50 ml of methanol and added with 200 mg of 10% palladium on carbon, followed by stirring for 2 hours in the stream of hydrogen gas. The catalyst was removed by filtration, the filtrate was condensed and the residue was recrystallized from ethanol to obtain 1.43 g of crystals. Yield: 79%

Workup

  1. customThe catalyst was removed by filtration
  2. customcondensed
  3. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-9e5b84e7364a46a68f92bfd58ab1eccf
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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