Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate | HCID 15290059 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 146737-36-2 | HCID 219052 | 91.1% |
Reaction Steps
16.5 g of ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl)indan-5-yl]acetate was suspended in 50 ml of 1N sodium hydroxide, and heated at 80° C. for 1 hour. After cooling, conc. HCl was added thereto to make the system acidic. The precipitates were collected by filtration, followed by recrystallization from 80% ethanol to obtain 14.0 g of colorless needles. Yield: 91%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05409956 |
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| Source dataset | uspto-grants-1995_04 |
|---|
| ORD ID | ord-d5a6b03f7f4542cfa00b68fc393f7026 |
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| Source note | uspto-grants-1995_04 |
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