Hydrochloric Acid → 146737-36-2

HRID 1654950Notes

Reaction equation

HRID 1654950 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:22][C:23]([O:25]CC)=[O:24])[CH:19]=3)[CH2:14]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH2:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:22][C:23]([OH:25])=[O:24])[CH:19]=3)[CH2:14]2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15290059Ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]-acetate

Product 1

HCID 219052146737-36-2Yield 91.1%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

16.5 g of ethyl [2-[(4-chlorophenyl)sulfonylaminomethyl)indan-5-yl]acetate was suspended in 50 ml of 1N sodium hydroxide, and heated at 80° C. for 1 hour. After cooling, conc. HCl was added thereto to make the system acidic. The precipitates were collected by filtration, followed by recrystallization from 80% ethanol to obtain 14.0 g of colorless needles. Yield: 91%

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitates were collected by filtration
  3. customfollowed by recrystallization from 80% ethanol

Sources & evidence

ORD record
ord-d5a6b03f7f4542cfa00b68fc393f7026
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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