Dichloromethane → HCID 18921490, compound

HRID 1654960Notes

Reaction equation

HRID 1654960 reaction equation
C([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][NH:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)(=[O:16])=[O:15])[CH2:6]2)=O.[C:24]([CH:29]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:26][CH2:27][CH3:28])=[O:25].[CH2:49](Cl)Cl>>[CH2:27]([O:26][C:24](=[O:25])/[CH:29]=[CH:49]/[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([CH2:12][NH:13][S:14]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)(=[O:15])=[O:16])[CH2:6]2)[CH3:28]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 18921503HCID 18921503, compound

Product 1

HCID 18921490HCID 18921490, compoundYield 77%

Procedure

To 20 ml of methylene chloride, 1.29 g (3.68 mmol) of 5-formyl-2-[(4-chlorophenyl)sulfonylaminomethyl]indan and 1.28 g (3.68 mmol) of carboethoxymethylene triphenylphosphoran were added and stirred for 16 hours at room temperature. The reaction solution was purified by silica gel column chromatography.(chloroform), and the precipitates obtained were recrystallized from a solvent mixture of ethyl acetate and hexane. 1.18 g of colorless crystals were obtained. Yield: 77%

Workup

  1. customThe reaction solution was purified by silica gel column chromatography
  2. custom(chloroform), and the precipitates obtained
  3. customwere recrystallized from a solvent mixture of ethyl acetate and hexane

Sources & evidence

ORD record
ord-90cbf094a0b64ec2a3ee250439464f38
Source dataset
uspto-grants-1995_04
Patent number
US05409956

Reaction notes

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