HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1654962Generated: November 2, 2026
Hydrochloric Acid → 3-[2-[(4-Chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionic acid
https://huagongshe.com/reaction/1654962
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl-3-[2-[(4-chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionate | HCID 18921500 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-[2-[(4-Chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionic acid | HCID 18921488 | 76% |
Reaction Steps
195 mg (0.50 mmol) of ethyl-3-[2-[(4chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionate was suspended in 3 ml of 2N sodium hydroxide and heated at 70° C. for 2 hours. After cooling, the system was made acidic with conc. HCl in an ice bath. The precipitated crystals were collected, recrystallized from a solvent mixture of ethyl acetate and hexane to obtain 137 mg of colorless flakes. Yield: 76%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05409956 |
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| Source dataset | uspto-grants-1995_04 |
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| ORD ID | ord-10bb35cc3a624979ae22d55606ff8d1b |
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| Source note | uspto-grants-1995_04 |
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