反应详情

温度

70 °C

195 mg (0.50 mmol) of ethyl-3-[2-[(4chlorophenyl)sulfonylaminomethyl]indan-5-yl]propionate was suspended in 3 ml of 2N sodium hydroxide and heated at 70° C. for 2 hours. After cooling, the system was made acidic with conc. HCl in an ice bath. The precipitated crystals were collected, recrystallized from a solvent mixture of ethyl acetate and hexane to obtain 137 mg of colorless flakes. Yield: 76%

1. temperatureAfter cooling
2. customThe precipitated crystals were collected
3. customrecrystallized from a solvent mixture of ethyl acetate and hexane
4. customto obtain 137 mg of colorless flakes